Thelma is a colorful and quick-witted 87-year-old woman battling her memory. Her devoted daughter Marilyn, with whom she now lives, is trying to make the best of the situation. Curtis, her neighbor, is a writer and stay-at-home father of a special-needs child. His wife, Kristie, struggles to balance family and work. When Marilyn asks Curtis to care for her mother and her beloved cats while she is at the beach, it sets in motion a friendship that tethers two families. Set in a small town in North Carolina, On Pine Knoll Street is an intimate look at the joy and fragility of life, the meaning of home, and the things we do for love.